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There are no specific, effective drug treatments for the lack of coordination seen with ataxia. Amantadine, buspirone hydrochloride (BuSpar) and modafinil (Provigil) are often tried with variable success. For episodic ataxia, acetazolamide (Diamox) or topiramate (Topamax) can be effective. Clonazepam (Klonopin) is effective in treating specific symptoms, such as muscle jerking (myoclonus) and sleep disturbances. Depression is common in patients with cerebellar ataxia. This is understandable in terms of the disability resulting from the condition. Recent research also indicates that patients with cerebellar ataxia may be prone to depression because of dysfunction of the cerebellum. Medication and emotional support are usually effective in treatment of depression in cerebellar ataxia.

Physical therapy, including stretching, conditioning and strengthening exercise, is also important. People who are not overweight, well conditioned, and flexible cope better with ataxia symptoms. Physical therapy and occupational therapy can also help evaluate the need for mobility and safety aids and help choose the appropriate aid for a particular patient. Home safety evaluations and recommendations for modifications are also performed more effectively by occupational therapists.

Speech therapy can help with evaluating swallowing and teaching the patient about how to speak clearly and avoid choking.

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